• ATPγS tetralithium salt Despite the observed declines in

  2019-08-11

  

  Despite the observed declines in lung cancer incidence rates among men, such favorable results probably do not reflect the recently-implemented tobacco control policies, given the relatively short ATPγS tetralithium salt between adoption and implementation of these measures, and the time lag assess

• Liver disease is the third

  2019-07-30

  

  Liver disease is the third most common cause of premature death in the UK [26]. Due to the increased incidence of obesity, NAFLD is now more prevalent than alcohol-induced liver disease [2] with 67% of overweight and 94% of obese individuals presenting this condition [27]. The HF/HFr regime was sele

• The B class scavenger receptor CD

  2019-07-24

  

  The B class scavenger receptor CD36 acts as a fibrillar Aβ receptor [40]. In our studies, acute OAB-14 treatment caused a remarkable increase in CD36 expression on the surface of microglia, which might be the main reason why microglia remove fibrillar Aβ. CD36-positive microglia are M2 microglia [41

• The present findings also show that paternal hyperglycemia i

  2019-07-24

  

  The present findings also show that paternal hyperglycemia induced hypermethylation of specific CpG dinucleotides in the Ppara promoter region of the offspring liver, rather than altering the methylation of all CpGs in the Ppara promoter, and the magnitude of variation in CpG methylation was suffici

• In addition to the liver

  2019-07-24

  

  In addition to the liver, muscle is a key target organ of insulin action as it stimulates the uptake and disposal of glucose to maintain blood glucose levels within the normal (physiological) range. Relative gene expression of glucose transporter type 4 (Glut4; −29%; p increases Liproxstatin-1 expen

• A second model recently developed using CRISPR Cas is the

  2019-07-08

  

  A second model recently developed using CRISPR/Cas9 is the CF rabbit, both CFTR null or carrying the ΔF508 mutation [50]. This model was also generated because of the need of an easy animal model that reproduces the lung phenotype. The CF rabbit is still at the initial characterization stage, but pr

• Adipose tissue is a major site for cholesterol storage

  2019-07-08

  

  Adipose tissue is a major site for cholesterol storage. Over half of total body cholesterol resides within the adipose tissues in obesity [[36], [37], [38]]. In EAT and SAT from high cholesterol diet (Western or HFD + Cho)-fed mice, we detected about 300–400 mg of cholesterol per gram of tissue, whe

• Pifithrin-α (PFTα) Since i melatonin inhibits biliary damage

  2019-07-08

  

  Since: (i) melatonin inhibits biliary damage and liver fibrosis by downregulation of miR-200b; and (ii) downregulation of miR-200b (by Vivo Morpholino) in Mdr2−/− mice decreases the Pifithrin-α (PFTα) of selected clock genes, we propose that the modulation of the melatonin/MT1/miR-200b/circadian rh

• Throughout all studies it was of interest that despite

  2019-07-08

  

  Throughout all studies, it was of interest that despite marked alterations in the top and middle bands by either proteasomal or lysosomal inhibitors, the effect on the bottom band was not significant nor consistent. Considering this, it could be suggested that the bottom band may not be result of su

• br Materials and methods br Results br Discussion Mistry et

  2019-07-08

  

  Materials and methods Results Discussion Mistry et al. have provided convincing data showing that targeting the BB loop pocket is an effective approach for the identification of TLR2 signaling inhibitors [35]. In our study, the combination of blind docking and subsequent MD simulations indi

• Functional and structural MRI is a strong tool to

  2019-07-06

  

  Functional and structural MRI is a strong tool to demonstrate brains in cancer survivors are different from brains of people not treated with chemotherapeutic agents or healthy people with no cancer, especially in the case patient who did not show big differences on neuropsychological tests compared

• br GM composition and physiological functions in health The

  2019-07-06

  

  GM composition and physiological functions in health The term microbiota refers to the living microbial community inhabit within a specific environment and encompasses bacteria, archaea, viruses (mainly phages), eukaryotes (mainly yeasts), even though bacteria outnumber the other domains. There i

• br Transparency document br Author

  2019-07-05

  

  Transparency document Author contributions Introduction Tau is a microtubule-associated protein found mainly in the neurons of vertebrates (for a review see [1]). Tau of distinct origin shows some variability in primary sequence. By splitting the tau molecule into two halves, greater variab

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